RECEPTOR-ACTIVATED CA2+ INFLUX - HOW MANY MECHANISMS FOR HOW MANY CHANNELS

被引：440
作者：
FASOLATO, C
INNOCENTI, B
POZZAN, T
机构：
[1] CNR Centre for the Study of Mitochondrial Physiology, University of Padova, 35131 Padova
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 1994年 / 15卷 / 03期
关键词：
D O I：
10.1016/0165-6147(94)90282-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Receptors that are coupled to the production of inositol (1,4,5)-trisphosphate cause an increase in cytosolic free Ca2+ concentration as a consequence of both Ca2+ mobilization from intracellular stores and Ca2+ influx through the plasma membrane. Although this latter phenomenon appears attributable to the activation of a number of Ca2+-permeable channels, the channels that are controlled by the Ca2+ content of the intracellular stores have recently received much attention. In this review, Cristina Fasolato, Barbara Innocenti and Tullio Pozzan summarize the characteristics of this Ca2+-influx pathway and discuss the hypotheses about its mechanism of activation and its relationship with other receptor-activated Ca2+ channels.
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页码：77 / 83
页数：7
相关论文
共 55 条
[1]   CYTOCHROME-P-450 MAY LINK INTRACELLULAR CA2+ STORES WITH PLASMA-MEMBRANE CA2+ INFLUX [J].
ALVAREZ, J ;
MONTERO, M ;
GARCIASANCHO, J .
BIOCHEMICAL JOURNAL, 1991, 274 :193-197
[2]  
BAHNSON TD, 1993, J BIOL CHEM, V268, P10808
[3]   A NOVEL RECEPTOR-OPERATED CA-2+-PERMEABLE CHANNEL ACTIVATED BY ATP IN SMOOTH-MUSCLE [J].
BENHAM, CD ;
TSIEN, RW .
NATURE, 1987, 328 (6127) :275-278
[4]   INOSITOL TRISPHOSPHATE AND CALCIUM SIGNALING [J].
BERRIDGE, MJ .
NATURE, 1993, 361 (6410) :315-325
[5]   ACTIVATION OF CA2+ ENTRY INTO ACINAR-CELLS BY A NON-PHOSPHORYLATABLE INOSITOL TRISPHOSPHATE [J].
BIRD, GS ;
ROSSIER, MF ;
HUGHES, AR ;
SHEARS, SB ;
ARMSTRONG, DL ;
PUTNEY, JW .
NATURE, 1991, 352 (6331) :162-165
[6]  
BIRD GS, 1993, J BIOL CHEM, V268, P21486
[7]   INHIBITION OF CA2+-DEPENDENT K+ TRANSPORT AND CELL DEHYDRATION IN SICKLE ERYTHROCYTES BY CLOTRIMAZOLE AND OTHER IMIDAZOLE DERIVATIVES [J].
BRUGNARA, C ;
DEFRANCESCHI, L ;
ALPER, SL .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (01) :520-526
[8]   EXCHANGE CHARACTERISTICS OF THE NORADRENALIN-SENSITIVE CALCIUM STORE IN VASCULAR SMOOTH-MUSCLE CELLS OF RABBIT EAR ARTERY [J].
CASTEELS, R ;
DROOGMANS, G .
JOURNAL OF PHYSIOLOGY-LONDON, 1981, 317 (AUG) :263-279
[9]  
CLEMENTI E, 1992, J BIOL CHEM, V267, P2164
[10]   MULTIPLE MECHANISMS OF MANGANESE-INDUCED QUENCHING OF FURA-2 FLUORESCENCE IN RAT MAST-CELLS [J].
FASOLATO, C ;
HOTH, M ;
PENNER, R .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1993, 423 (3-4) :225-231
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