NEUROPROTECTIVE AND ANTIOXIDANT ACTIVITIES OF HU-211, A NOVEL NMDA RECEPTOR ANTAGONIST

被引：80

作者：

ESHHAR, N ^{[1
]}

STRIEM, S ^{[1
]}

KOHEN, R ^{[1
]}

TIROSH, O ^{[1
]}

BIEGON, A ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,SCH PHARM,DEPT PHARM,IL-91120 JERUSALEM,ISRAEL

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 283卷 / 1-3期

关键词：

TOXICITY; ANTIOXIDANT; FREE RADICAL; NMDA RECEPTOR; CORTICAL CULTURE;

D O I：

10.1016/0014-2999(95)00271-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study examines the ability of (+)-(3S,4S)-7-hydroxy-Delta(6)-tetrahydrocannabinol-1,1-dimethylheptyl (HU-211), a non-competitive NMDA receptor antagonist to: (1) rescue neurons in culture from injury evoked by sodium nitroprusside, hydrogen peroxide (H2O2) and oxygen glucose deprivation; and (2) scavenge reactive oxygen species in vitro. Qualitative and quantitative assessments of cell survival have indicated that: (1) Neuronal cell injury produced following deprivation of oxygen and glucose was significantly attenuated by 5 mu M HU-211. (2) Glial and neuronal cell damage induced by sodium nitroprusside was markedly ameliorated by 10 mu M HU-211. (3) HU-211 reduced protein oxidation initiated by gamma irradiation, and scavenged peroxyl radicals. (4) HU-211 carries an oxidation potential of 550 mV. These findings suggest that HU-211 holds a unique position among putative neuroprotectant agents in that it combines NMDA receptor antagonistic activity and free radical scavenging abilities in a single molecule.

引用

页码：19 / 29

页数：11

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