THE EFFECTS OF DISULFIRAM ON THE HIPPOCAMPUS AND CEREBELLUM OF THE RAT-BRAIN - A STUDY ON OXIDATIVE STRESS

被引：38
作者：
DELMAESTRO, E [1 ]
TROMBETTA, LD [1 ]
机构：
[1] ST JOHNS UNIV,COLL PHARM & ALLIED HLTH PROFESS,TOXICOL PROGRAM,JAMAICA,NY 11439
来源：
TOXICOLOGY LETTERS | 1995年 / 75卷 / 1-3期
关键词：
DISULFIRAM; OXIDATIVE STRESS; COPPER; LIPID PEROXIDATION; HIPPOCAMPUS; CEREBELLUM;
D O I：
10.1016/0378-4274(94)03187-C
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The purpose of this investigation was to study the relationship between disulfiram (DS) toxicity, lipid peroxidation, and copper in order to further elucidate the mechanisms of DS toxicity. Male Sprague-Dawley rats were dosed with either 375, 750 or 1500 mg/kg disulfiram via oral intubation for 1, 3 and 6 weeks. In the hippocampus and cerebellum, the increased accumulation of copper, increased production of malondialdehyde (MDA), increased activity of glutathione peroxidase along with alterations in glutathione and glutathione disulfide concentrations was indicative of oxidative stress. The production of MDA was directly related to the level of copper in both areas of the brain indicating that excess copper may be the primary cause of DS neurotoxicity.
引用
收藏
页码：235 / 243
页数：9
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