MOLECULAR APPROACHES FOR THE TREATMENT OF HEMORRHAGIC-FEVER VIRUS-INFECTIONS

被引:79
作者
ANDREI, G
DECLERCQ, E
机构
[1] Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven
关键词
HEMORRHAGIC FEVER VIRUSES; RIBAVIRIN; PYRAZOFURIN; CYCLOPENTYLCYTOSINE; NEPLANOCIN-A; SULFATED POLYMERS; INTERFERON; IMMUNOMODULATORS;
D O I
10.1016/0166-3542(93)90085-W
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Viruses causing hemorrhagic fevers in man belong to the following virus groups: togavirus (Chikungunya), flavivirus (dengue, yellow fever, Kyasanur Forest disease, Omsk hemorrhagic fever), arenavirus (Argentinian hemorrhagic fever, Bolivian hemorrhagic fever, Lassa fever), filovirus (Ebola, Marburg), phlebovirus (Rift Valley fever), nairovirus (Crimian-Congo hemorrhagic fever) and hantavirus (hemorrhagic fever with renal syndrome, nephropathic epidemia). Hemorrhagic fever virus infections can be approached by different therapeutic strategies: (i) vaccination; (ii) administration of high-titered antibodies; and (iii) treatment with antiviral drugs. Depending on the molecular target of their interaction, antiviral agents could be classified as follows: IMP dehydrogenase inhibitors (i.e., ribavirin and its derivatives); OMP decarboxylase inhibitors (i.e., pyrazofurin); CTP synthetase inhibitors (i.e., cyclopentylcytosine and cyclopentenylcytosine); SAH hydrolase inhibitors (i.e., neplanocin A); polyanionic substances (i.e., sulfated polymers); interferon and immunomodulators.
引用
收藏
页码:45 / 75
页数:31
相关论文
共 145 条
[1]   ORAL DEXTRAN SULFATE (UA001) IN THE TREATMENT OF THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) AND AIDS-RELATED COMPLEX [J].
ABRAMS, DI ;
KUNO, S ;
WONG, R ;
JEFFORDS, K ;
NASH, M ;
MOLAGHAN, JB ;
GORTER, R ;
UENO, R .
ANNALS OF INTERNAL MEDICINE, 1989, 110 (03) :183-188
[2]   INHIBITORY EFFECT OF SELECTED ANTIVIRAL COMPOUNDS ON ARENAVIRUS REPLICATION INVITRO [J].
ANDREI, G ;
DECLERCQ, E .
ANTIVIRAL RESEARCH, 1990, 14 (4-5) :287-300
[3]  
ARROYO JI, 1988, AM J TROP MED HYG, V38, P647
[4]   CONSTRUCTION OF A RECOMBINANT VACCINIA VIRUS EXPRESSING THE LASSA VIRUS GLYCOPROTEIN GENE AND PROTECTION OF GUINEA-PIGS FROM A LETHAL LASSA VIRUS-INFECTION [J].
AUPERIN, DD ;
ESPOSITO, JJ ;
LANGE, JV ;
BAUER, SP ;
KNIGHT, J ;
SASSO, DR ;
MCCORMICK, JB .
VIRUS RESEARCH, 1988, 9 (2-3) :233-248
[5]  
BABA M, 1990, J ACQ IMMUN DEF SYND, V3, P493
[6]   PENTOSAN POLYSULFATE, A SULFATED OLIGOSACCHARIDE, IS A POTENT AND SELECTIVE ANTI-HIV AGENT INVITRO [J].
BABA, M ;
NAKAJIMA, M ;
SCHOLS, D ;
PAUWELS, R ;
BALZARINI, J ;
DECLERCQ, E .
ANTIVIRAL RESEARCH, 1988, 9 (06) :335-343
[7]   NOVEL SULFATED POLYMERS AS HIGHLY POTENT AND SELECTIVE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-REPLICATION AND GIANT-CELL FORMATION [J].
BABA, M ;
SCHOLS, D ;
DECLERCO, E ;
PAUWELS, R ;
NAGY, M ;
GYORGYIEDELENYI, J ;
LOW, M ;
GOROG, S .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (01) :134-138
[8]   MECHANISM OF INHIBITORY EFFECT OF DEXTRAN SULFATE AND HEPARIN ON REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS INVITRO [J].
BABA, M ;
PAUWELS, R ;
BALZARINI, J ;
ARNOUT, J ;
DESMYTER, J ;
DECLERCQ, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (16) :6132-6136
[9]   SULFATED POLYSACCHARIDES ARE POTENT AND SELECTIVE INHIBITORS OF VARIOUS ENVELOPED VIRUSES, INCLUDING HERPES-SIMPLEX VIRUS, CYTOMEGALO-VIRUS, VESICULAR STOMATITIS-VIRUS, AND HUMAN IMMUNODEFICIENCY VIRUS [J].
BABA, M ;
SNOECK, R ;
PAUWELS, R ;
DECLERCQ, E .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (11) :1742-1745
[10]   NOVEL SULFATED POLYSACCHARIDES - DISSOCIATION OF ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS ACTIVITY FROM ANTITHROMBIN ACTIVITY [J].
BABA, M ;
DECLERCQ, E ;
SCHOLS, D ;
PAUWELS, R ;
SNOECK, R ;
VANBOECKEL, C ;
VANDEDEM, G ;
KRAAIJEVELD, N ;
HOBBELEN, P ;
OTTENHEIJM, H ;
DENHOLLANDER, F .
JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (02) :208-213