SYNTHESIS OF (R)-5-(HYDROXYMETHYL)-3-ISOPROPYLOXAZOLIDIN-2-ONE AND (S)-5-(HYDROXYMETHYL)-3-ISOPROPYLOXAZOLIDIN-2-ONE, INTERMEDIATES IN THE PREPARATION OF OPTICALLY-ACTIVE BETA-BLOCKERS

被引：11
作者：
WARMERDAM, EGJC
BRUSSEE, J
VANDERGEN, A
KRUSE, CG
机构：
[1] LEIDEN UNIV,GORLAEUS LABS,DEPT CHEM,2300 RA LEIDEN,NETHERLANDS
[2] SOLVAY DUPHAR BV,1380 DA WEESP,NETHERLANDS
来源：
HELVETICA CHIMICA ACTA | 1994年 / 77卷 / 01期
关键词：
D O I：
10.1002/hlca.19940770127
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The (R)- and (S)-5-(hydroxymethyl)-3-isopropyloxazolidin-2-ones, ((R)- and (S)-2, resp.), pivotal intermediates in the preparation of optically active beta-blockers, were synthesized using (R,E)-2-hydroxypent-3-enenitrile (1) as the chiral starting material. In the synthesis of(R)-2, a known cyclization/inversion step was applied.
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页码：252 / 256
页数：5
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