CAPILLARY ELECTROPHORESIS MASS-SPECTROMETRY

The developments and state-of-the-art in capillary electrophoresis-mass spectrometry (CE-MS) are reviewed and evaluated. Attention is paid to interfaces for CE-MS, the coupling of CE to the interface, applications of CE-MS in both qualitative and quantitative analysis, CE buffer composition and the coupling of other electromigration techniques to MS. The state-of-the-art is critically reviewed. Special attention is paid to the achievable concentration detection limits, because the present limits in the low-ppm range prohibit the broad analytical use of the CE-MS technique. Current approaches to solving or removing these problems are discussed.