NATURALLY-OCCURRING SLE ANTI-DNA ANTIBODIES RECOGNIZE UNIQUE CONFORMATION ON DNA-LYSINE PHOTOADDUCT

被引：15

作者：

ALAM, K ^{[1
]}

ISLAM, N ^{[1
]}

HASAN, R ^{[1
]}

ALI, A ^{[1
]}

ALI, R ^{[1
]}

机构：

[1] ALIGARH MUSLIM UNIV,FAC MED,DEPT BIOCHEM,ALIGARH 202002,INDIA

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1992年 / 36卷 / 09期

关键词：

D O I：

10.1111/j.1348-0421.1992.tb02104.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Native calf thymus DNA has been covalently modified with lysine under UV-A light. Human autoantibodies on purification through affinity column of native DNA linked to polylysyl-Sepharose 4B showed almost equal recognition of DNA and photoadduct. The recognition of DNA-lysine photoadduct by the affinity-purified autoantibodies might be helpful in understanding their origin in SLE vis-a-vis the role of positively charged amino acids in the pathogenesis of autoimmune diseases.

引用

页码：1003 / 1007

页数：5

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