USE OF POLYPHOSPHORIC ACID IN POMERANZ-FRITSCH SYNTHESIS OF ISOQUINOLINES

被引：9

作者：

BEVIS, MJ

FORBES, EJ

UFF, BC

机构：

[1] Department of Chemistry, University of Birmingham, Birmingham

来源：

TETRAHEDRON | 1969年 / 25卷 / 07期

关键词：

D O I：

10.1016/S0040-4020(01)82730-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A number of 7,8 and 1-substituted isoquinolines have been synthesized by the Pomeranz-Fritsch procedure using polyphosphoric acid as cyclizing agent. Though giving only moderate yields the method was successful in all cases, particularly for the preparation of 8-substituted isoquinolines, which in most cases are unobtainable from cyclization using sulphuric acid. In addition, the 12H-[1]-benzoxepino[2.3.4-ij]isoquinoline system, present in the cularine alkaloids, has been elaborated. © 1969.

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页码：1585 / +

页数：1

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