DISTINCT EXPRESSION AND SHARED ACTIVITIES OF MEMBERS OF THE HEDGEHOG GENE FAMILY OF XENOPUS-LAEVIS

被引:0
作者
EKKER, SC
MCGREW, LL
LAI, CJ
LEE, JJ
VONKESSLER, DP
MOON, RT
BEACHY, PA
机构
[1] UNIV WASHINGTON, SCH MED, DEPT PHARMACOL, SEATTLE, WA 98195 USA
[2] HOWARD HUGHES MED INST, SEATTLE, WA 98195 USA
[3] JOHNS HOPKINS UNIV, SCH MED, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA
[4] HOWARD HUGHES MED INST, BALTIMORE, MD 21205 USA
来源
DEVELOPMENT | 1995年 / 121卷 / 08期
关键词
HEDGEHOG; NEURAL INDUCTION; CEMENT GLAND; FOLLISTATIN; NOGGIN; XENOPUS LAEVIS;
D O I
暂无
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The hedgehog family of signaling proteins is associated with a variety of spatial patterning activities in insects and vertebrates. Here we show that new members of this family isolated from Xenopus laevis are expressed embryonically in patterns suggestive of roles in patterning in the ectoderm, nervous system and somites, Banded hedgehog is expressed throughout the neural plate and subsequently in both the nervous sf;stem and in the dermatome of somites, Cephalic hedgehog is expressed in anterior ectoderm and endodermal structures, and sonic hedgehog is expressed in patterns which parallel those in other species. Injection of RNAs encoding Xenopus hedgehogs induces ectopic cement gland formation in embryos, Similar to reported activities of noggin and follistatin, Xenopus hedgehogs share a common ability to induce cement glands in animal cap explants. However, hedgehog activities in naive ectoderm appear capable of acting independently of noggin and follistatin since, although all three are induced by activin in animal cap explants, X-hh expression does not induce noggin or follistatin.
引用
收藏
页码:2337 / 2347
页数:11
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