BENZYLIDENE CYCLOPENTANONE DERIVATIVES AS INHIBITORS OF RAT LIVER GLUTATHIONE S-TRANSFERASE ACTIVITIES

被引:0
作者
Martono, Sudibyo [1 ]
机构
[1] Gadjah Mada Univ, Fac Pharm, Lab Pharmaceut Chem, Yogyakarta, Indonesia
关键词
curcumin; benzylidene cyclopentanone; inhibitory potency; glutathione S-transferases mesoporous;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The effect of the curcumin analogues, 2,6-bis-(4-hydroxy-3-methoxy benzylidene) cyclopentanone (B1) and two of its derivatives on mu class glutathione S-transferases (GSTs) from phenobarbital-induced and uninduced rat liver cytosol has been studied to elucidate their anti-inflammatory activity. GST activity was monitored spectrophotometrically using 1,2-dichloro-4-nitrobenzene. B1 was the most potent inhibitor of GSTs, both in uninduced and in phenobarbital-induced rat liver cytosol. These inhibitory properties might be explained as part of the anti-inflammatory activity of benzylidene cyclopentanone derivatives (B1 and B12).
引用
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页码:71 / 75
页数:5
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