MAPPING OF A LIVER PHOSPHORYLASE-KINASE ALPHA-SUBUNIT GENE ON THE MOUSE X-CHROMOSOME

Phosphorylase kinase (PHK) is a regulatory enzyme of the glycogenolytic pathway composed of a complex of four subunits. We recently mapped the muscle α-subunit gene (Phka) to the mouse X chromosome in a region syntenic with the proximal long arm of the human X chromosome and containing the human homologue of this gene, PHKA. We now report the mapping of the liver α-subunit gene to the telomeric end of the mouse X chromosome. This mapping position would suggest a location for the human liver α-subunit gene on the proximal short arm of the X chromosome, a region recently implicated in X-linked liver glycogenosis (XLG). © 1993 Academic Press, Inc.