Synthesis and antimicrobial activity of nitrazepam (7-nitro-1,3-dihydro-5-phenyl-2h-1,4-benzodiazepine-2-one) (drug) complexes of rare earth metals

Metal complexes of Th (IV), Ce (IV) and UO2 (IV) with drug nitrazepam (NZ) (7-nitro-1,3dihydro- 5-phenyl-2H-1,4- benzodiazepine-2-one) have been synthesized and characterized with the help of elemental analysis and IR spectral data. On the basis of IR spectral data the band in the free ligand attributed to upsilon (C = N) & upsilon (N-H) undergoes the shifting to lower region in all the complexes, indicating the participation of azomethine nitrogen N (4) & N (1) in complexation. All the coloured complexes have been screened for their antimicrobial activity against fungi viz. A. niger, A. flavous, P. triticena, Fusarium species and bacteria viz. E. coli, B. subtilis, S. typhi, S. aureus. The results of antimicrobial activity show that Nz-metal complexes of tetravalent metals have more potency towards experimental fungi and bacteria. It also shows that Th (IV) complex is more toxic against bacteria E. coli.