APOMORPHINE DISRUPTS ODOR-INDUCED PATTERNS OF GLOMERULAR ACTIVATION IN THE OLFACTORY-BULB

被引：43

作者：

SALLAZ, M ^{[1
]}

JOURDAN, F ^{[1
]}

机构：

[1] UNIV LYON 1,CNRS,43 BLVD 11 NOVEMBRE 1918,F-69622 VILLEURBANNE,FRANCE

来源：

NEUROREPORT | 1992年 / 3卷 / 10期

关键词：

OLFACTORY BULB; 2-DEOXYGLUCOSE; DOPAMINE; APOMORPHINE;

D O I：

10.1097/00001756-199210000-00003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE olfactory bulb of adult male rats stimulated with propionic acid vapours displays a characteristic focus of high metabolic activity in the dorso-medial glomeruli, as revealed by the 2-deoxyglucose (2DG) method. Injection of the dopaminergic agonist apomorphine (1.5 mg kg-1) prior to odour stimulation completely abolishes this selective pattern of glomerular activation, while the metabolic activity of other bulbar areas is not significantly altered. This effect is abolished by a previous injection of the dopamine antagonist haloperidol (0.1 mg kg-1). These observations emphasize the probable involvement of dopamine and dopamine receptors in the bulbar processing of olfactory information.

引用

页码：833 / 836

页数：4

共 12 条

[1] VISUAL DEFICITS RELATED TO DOPAMINE DEFICIENCY IN EXPERIMENTAL-ANIMALS AND PARKINSONS-DISEASE PATIENTS [J].

BODISWOLLNER, I .

TRENDS IN NEUROSCIENCES, 1990, 13 (07) :296-302

[2] OLFACTORY DYSFUNCTION IN PARKINSONISM - A GENERAL DEFICIT UNRELATED TO NEUROLOGIC SIGNS, DISEASE STAGE, OR DISEASE DURATION [J].

DOTY, RL ;

DEEMS, DA ;

STELLAR, S .

NEUROLOGY, 1988, 38 (08) :1237-1244

[3] INFLUENCE OF THE D-2 DOPAMINE RECEPTOR AGONIST QUINPIROLE ON THE ODOR DETECTION PERFORMANCE OF RATS BEFORE AND AFTER SPIPERONE ADMINISTRATION [J].

DOTY, RL ;

RISSER, JM .

PSYCHOPHARMACOLOGY, 1989, 98 (03) :310-315

[4] EVIDENCE FOR COEXISTENCE OF GABA AND DOPAMINE IN NEURONS OF THE RAT OLFACTORY-BULB [J].

GALL, CM ;

HENDRY, SHC ;

SEROOGY, KB ;

JONES, EG ;

HAYCOCK, JW .

JOURNAL OF COMPARATIVE NEUROLOGY, 1987, 266 (03) :307-318

[5] TRANSMITTER HISTOCHEMISTRY OF RAT OLFACTORY-BULB .1. IMMUNOHISTOCHEMICAL LOCALIZATION OF MONOAMINE SYNTHESIZING ENZYMES - SUPPORT FOR INTRABULBAR, PERIGLOMERULAR DOPAMINE NEURONS [J].

HALASZ, N ;

LJUNGDAHL, A ;

HOKFELT, T ;

JOHANSSON, O ;

GOLDSTEIN, M ;

PARK, D ;

BIBERFELD, P .

BRAIN RESEARCH, 1977, 126 (03) :455-474

[6]

Hokfelt T, 1984, HDB CHEM NEUROANATOM, V2, P277

[7] SPATIAL-DISTRIBUTION OF [C-14]2-LABELED DEOXYGLUCOSE UPTAKE IN THE OLFACTORY BULBS OF RATS STIMULATED WITH 2 DIFFERENT ODORS [J].

JOURDAN, F ;

DUVEAU, A ;

ASTIC, L ;

HOLLEY, A .

BRAIN RESEARCH, 1980, 188 (01) :139-154

[8] DISTRIBUTION OF EFFECTS OF HALOPERIDOL ON ENERGY-METABOLISM IN THE RAT-BRAIN [J].

MCCULLOCH, J ;

SAVAKI, HE ;

SOKOLOFF, L .

BRAIN RESEARCH, 1982, 243 (01) :81-90

[9] THE DISTRIBUTION OF ALTERATIONS IN ENERGY-METABOLISM IN THE RAT-BRAIN PRODUCED BY APOMORPHINE [J].

MCCULLOCH, J ;

SAVAKI, HE ;

MCCULLOCH, MC ;

JEHLE, J ;

SOKOLOFF, L .

BRAIN RESEARCH, 1982, 243 (01) :67-80

[10] OLFACTORY-BULB DA RECEPTORS MAY BE LOCATED ON TERMINALS OF THE OLFACTORY NERVE [J].

NICKELL, WT ;

NORMAN, AB ;

WYATT, LM ;

SHIPLEY, MT .

NEUROREPORT, 1991, 2 (01) :9-12

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