N-SULFONYL DERIVATIVES OF 6,7-DICHLORO 3,4-DIHYDRO-3-OXO-QUINOXALINECARBOXYLATE AS GLYCINE-SITE NMDA AND AMPA ANTAGONISTS

被引：13

作者：

HAYS, SJ

BOXER, PA

TAYLOR, CP

VARTANIAN, MG

ROBICHAUD, LJ

NIELSEN, EO

机构：

[1] Parke-Davis Pharmaceutical Research Division Warner-Lambert Company, Ann Arbor, MI 48105

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80095-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-Phenylsulfonyl and N-methylsulfonyl derivatives of 6,7-dichloro-3,4-dihydro-3-oxo-2-quinoxalinecarboxamide have been synthesized. Both compounds have been characterized as antagonists, at the glycine-site of the NMDA receptor and AMPA receptor.

引用

页码：77 / 80

页数：4