N-SULFONYL DERIVATIVES OF 6,7-DICHLORO 3,4-DIHYDRO-3-OXO-QUINOXALINECARBOXYLATE AS GLYCINE-SITE NMDA AND AMPA ANTAGONISTS

被引：13
作者：
HAYS, SJ
BOXER, PA
TAYLOR, CP
VARTANIAN, MG
ROBICHAUD, LJ
NIELSEN, EO
机构：
[1] Parke-Davis Pharmaceutical Research Division Warner-Lambert Company, Ann Arbor, MI 48105
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 01期
关键词：
D O I：
10.1016/S0960-894X(00)80095-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
N-Phenylsulfonyl and N-methylsulfonyl derivatives of 6,7-dichloro-3,4-dihydro-3-oxo-2-quinoxalinecarboxamide have been synthesized. Both compounds have been characterized as antagonists, at the glycine-site of the NMDA receptor and AMPA receptor.
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页码：77 / 80
页数：4
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