PROPRANOLOL-METHACRYLIC ACID COPOLYMER BINDING INTERACTION

被引：24

作者：

LEE, HK

HAJDU, J

MCGOFF, P

机构：

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 02期

关键词：

D O I：

10.1002/jps.2600800220

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The polyanionic form of methacrylic acid:methacrylic acid methyl ester copolymer reacts readily with propranolol.HCI to give a sparingly soluble complex at saturation equilibrium. Propranolol: methacrylic acid copolymer complex is characterized by differential thermal analysis, and IR and UV spectroscopic methods. Propranolol content is found to be 68% in the complex. The value of the Hill coefficient (1.5) indicates that there is a high degree of positive cooperative interaction between propranolol and the polymer.

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页码：178 / 180

页数：3

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