ANTITUMOR EFFECTS OF PALM CAROTENES AND TOCOTRIENOLS IN HRS/J HAIRLESS FEMALE MICE

被引:13
|
作者
TAN, B
机构
[1] Department of Food Science, University of Massachusetts, Amherst
关键词
ANTITUMOR EFFECTS; CAROTENOIDS; TOCOTRIENOLS; BETA-CAROTENE AND ALPHA-CAROTENE; ALPHA-TOCOPHEROL;
D O I
10.1016/S0271-5317(05)80461-0
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The effect of palm carotenes (PC) and palm tocotrienols (T3) on the development of papilloma (chemical-induced skin cancer) and lymphoma (viral-induced lymph cancer) was studied in genetically recessive HRS/J female hairless mice. The two T3 groups had delayed response (2-4 weeks) to subcutaneous lymphoma (SL) formation when compared to the +ve Control group. The order of this SL inhibition phenomenon by PC in the feed was concentration dependent; 0.3% PC > 0.1% PC > 0.05% PC groups. The onset of SL in 0.3% synthetic carotene (SC) group was sooner than the 0.3% PC group. The +ve Control mice had significantly higher (> 2-fold) epithelial papilloma (EP) than the next group, 0.1% T3. All the PC groups completely inhibited EP formation after the mice were 7 months old. The "no EP" groups (0.1% PC, 0.3% PC, mixed, 0.3% S C) responded as if there was no application of DMBA-croton oil. Mechanisms of inhibition by T3 and PC were different. The T3 groups delayed but not regressed SL formation but the PC groups caused SL regression in a concentration dependent fashion. The 0.3% PC group showed the strongest antitumorigenic effect (and the least toxic effect with respect to mortality) while the 0.1% T3 group showed the least antitumorigenic effect to SL and EP formation.
引用
收藏
页码:S163 / S173
页数:11
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