THE IMMUNE-RESPONSE TO MYCOBACTERIAL HEAT-SHOCK PROTEINS

被引：12

作者：

YOUNG, DB

机构：

[1] MRC Tuberculosis and Related Infections Unit, RPMS, Hammersmith Hospital, London, W12 OHS, Ducane Road

来源：

AUTOIMMUNITY | 1990年 / 7卷 / 04期

关键词：

Antigens; Autoimmunity; Heat shock proteins;

D O I：

10.3109/08916939009087583

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Several prominent protein antigens involved in antibody and T cell responses to mycobacteria have been identified as members of highly conserved heat shock protein families. The immunogenicity of heat shock proteins in a broad range of infections, along with the extensive sequence identity between corresponding host and pathogen homologues, and the potential for localized accumulation in response to stress stimuli, makes these antigens attractive candidates for theories of autoimmunity based on "molecular mimicry" The 65 kilodalton (kD) heat shock protein of mycobacteria has indeed been shown to modulate the course of autoimmune disease in experimental animals, and immune responses to this and other heat shock proteins have been demonstrated in association with human autoimmune diseases. This paper provides a brief review of the immune response to mycobacterial heat shock proteins during infection and auto-immunity. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：237 / 244

页数：8

共 30 条

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