DETERMINATION OF ETHYLENE-OXIDE, ETHYLENE CHLOROHYDRIN, AND ETHYLENE-GLYCOL RESIDUES IN OPHTHALMIC SOLUTIONS AT PROPOSED CONCENTRATION LIMITS

被引：10

作者：

MANIUS, GJ

机构：

[1] Quality Control Department, Hoffmann-La Roche, Inc., Nutley, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 12期

关键词：

Ethylene chlorohydrin—analysis; GLC; ophthalmic solutions; Ethylene glycol—analysis; Ethylene oxide—analysis; GLC—analysis; ethylene oxide; ethylene chlorohydrin; ethylene glycol;

D O I：

10.1002/jps.2600681223

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A GLC method was developed for the determination of ethylene oxide and its two reaction products, ethylene chlorohydrin and ethylene glycol, in ophthalmic solutions at the levels recently proposed by the Food and Drug Administration. The method requires no extractions, sample preparations, or elaborate trapping and concentrating techniques. All three components can be chromatographed on the same spiral glass column packed with a porous polymer adsorbent. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1547 / 1549

页数：3

共 16 条

[1] RESIDUAL ETHYLENE OXIDE AND ETHYLENE GLYCOL IN ETHYLENE OXIDE STERILIZED PHARMACEUTICALS [J].