Clinical factors associated with Guillain-Barre syndrome following surgery

被引:27
|
作者
Hocker, Sara [1 ]
Nagarajan, Elanagan [1 ,3 ]
Rubin, Mark [2 ]
Wijdicks, Eelco F. M. [1 ]
机构
[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA
[2] Northshore Univ Hlth Syst, Dept Neurol, Glenview, IL USA
[3] Univ Missouri, Dept Neurol, Columbia, MO 65211 USA
关键词
D O I
10.1212/CPJ.0000000000000451
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background We sought to identify clinical associations and potential triggers of Guillain-Barre syndrome (GBS) within 6 weeks of surgery. Methods We retrospectively reviewed consecutive patients diagnosed with GBS within 6 weeks of a surgery between January 1995 and June 2014 at Mayo Clinic. Postsurgical GBS was defined as symptom onset within 6 weeks of surgery. Patients with postsurgical GBS were compared with patients who did not have a surgery prior to GBS onset to determine differences between groups. Results A total of 208 patients with GBS, median age 55 years (interquartile range [IQR] 41-68), were included. Nineteen patients (9.1%) developed postsurgical GBS. Median duration from the surgery to onset of first GBS symptom was 15 days (IQR 9-37). The main types of surgeries preceding GBS were gastrointestinal, orthopedic, and cardiac. General anesthesia was used in 18 (95%) and conscious sedation in 1 (5%) patient. Among the 19 patients with postsurgical GBS, 11 (57.9%) had a known diagnosis of malignancy. Autoimmune conditions were present in 5 (26.3%) patients. Postoperative infection was found in 4 (21%) patients. On univariate analysis, the factors that showed an association with postsurgical GBS were age (p = 0.02), malignancy (p = 0.0004), active malignancy (p = 0.03), preexisting autoimmune disorder (p = 0.02), and infection (p = 0.0001). On multivariate analysis, only active malignancy (0.03) remained associated. Conclusions Surgery antedated GBS in 9.1% of patients. Postsurgical GBS was more common in patients with an active malignancy. A prospective study is needed to determine whether active malignancy represents an independent risk factor for the development of postsurgical GBS.
引用
收藏
页码:201 / 206
页数:6
相关论文
共 50 条
  • [21] Guillain-Barre syndrome following dengue fever
    Chen, Ting-Yi
    Lee, Ching-Tai
    ANNALS OF EMERGENCY MEDICINE, 2007, 50 (01) : 94 - 95
  • [22] The Guillain-Barre syndrome following dengue fever
    Esack, A
    Teelucksingh, S
    Singh, N
    WEST INDIAN MEDICAL JOURNAL, 1999, 48 (01): : 36 - 37
  • [23] Guillain-Barre Syndrome Following a Human Bite
    Manji, Samira Khan
    Manji, Gulam Abbas
    Patel, Archana
    Patel, Mehul
    Sami, Arshad
    NEUROLOGY, 2011, 76 (09) : A158 - A158
  • [24] Guillain-Barre syndrome following hepatitis E
    Loly, Jean Philippe
    Rikir, Estelle
    Seivert, Maxime
    Legros, Emile
    Defrance, Pierre
    Belaiche, Jacques
    Moonen, Gustave
    Delwaide, Jean
    WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (13) : 1645 - 1647
  • [25] Guillain-Barre syndrome following influenza vaccination
    Haber, P
    DeStefano, F
    Angulo, FJ
    Iskander, J
    Shadomy, SV
    Weintraub, E
    Chen, RT
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 292 (20): : 2478 - 2481
  • [26] Guillain-Barre Syndrome and Postbariatric Surgery Polyneuropathies
    Aluka, Kanayochukwu J.
    Turner, Patricia L.
    Fullum, Terrence M.
    JSLS-JOURNAL OF THE SOCIETY OF LAPAROENDOSCOPIC SURGEONS, 2009, 13 (02) : 250 - 253
  • [27] Recurrent Guillain-Barre Syndrome Following Vaccination
    Baxter, Roger
    Lewis, Ned
    Bakshi, Nandini
    Vellozzi, Claudia
    Klein, Nicola P.
    CLINICAL INFECTIOUS DISEASES, 2012, 54 (06) : 800 - 804
  • [28] Guillain-Barre Syndrome Following Spinal Anaesthesia
    Sayin, Refah
    Kati, Ismail
    Isik, Yasemin
    Gunes, Mustafa
    JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN, 2013, 23 (06): : 440 - 442
  • [29] Recurrent Guillain-Barre syndrome after surgery
    Olivier, N.
    Laribi, H.
    Pages, M.
    Camu, W.
    Morales, R. Juntas
    REVUE NEUROLOGIQUE, 2010, 166 (6-7) : 644 - 647
  • [30] Yellow nail syndrome following Guillain-Barre syndrome
    Woollons, A
    Darley, CR
    CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1997, 22 (05) : 253 - 254