SIGNALING BY HEDGEHOG FAMILY PROTEINS IN DROSOPHILA AND VERTEBRATE DEVELOPMENT

被引：100
作者：
INGHAM, PW
机构：
[1] Molecular Embryology Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 04期
关键词：
D O I：
10.1016/0959-437X(95)90054-K
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Members of the hedgehog gene family encode a novel class of secreted proteins and are expressed in embryonic cells known to possess Important signalling activities in organisms as diverse as flies and chickens. Proteins of the hedgehog family act in these different developmental contexts as both permissive and instructive signals. How this signalling activity is transduced is (as yet) poorly understood, but recent studies point to the involvement of protein kinase A in both Drosophila acid vertebrates.
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页码：492 / 498
页数：7
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