THE EFFECT OF SILIBININ (LEGALON(R)) ON THE FREE-RADICAL SCAVENGER MECHANISMS OF HUMAN ERYTHROCYTES IN-VITRO

被引：0

作者：

ALTORJAY, I

DALMI, L

SARI, B

IMRE, S

BALLA, G

机构：

[1] DEBRECEN UNIV MED,SCH MED,DEPT MED 2,H-4012 DEBRECEN,HUNGARY

[2] DEBRECEN UNIV MED,SCH MED,DEPT PATHOPHYSIOL,H-4012 DEBRECEN,HUNGARY

[3] DEBRECEN UNIV MED,SCH MED,DEPT PEDIAT,H-4012 DEBRECEN,HUNGARY

来源：

ACTA PHYSIOLOGICA HUNGARICA | 1992年 / 80卷 / 1-4期

关键词：

LEGALON(R); FREE RADICAL SCAVENGER MECHANISMS; DYNAMIC HEMOLYSIS CURVE; ERYTHROCYTES;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The effect of LegalonR was investigated parallel with that of AdriblastinaR (doxorubicin) and paracetamol on some parameters characterizing the free radical scavenger mechanisms of human erythrocytes in vitro and on the time of acid haemolysis performed in aggregometer. Observations suggest that Adriblastina enhances the lipid peroxidation of the membrane of red blood cells, while paracetamol causes significant depletion of intracellular glutathione level, thus decreasing the free radical eliminating capacity of the glutathione peroxidase system. LegalonR on the other hand, is able to increase the activity of both superoxide dismutase and glutathione peroxidase, which may explain the protective effect of the drug against free radicals and also the stabilizing effect on the red blood cell membrane, shown by the increase of the time of full haemolysis.

引用

页码：375 / 380

页数：6

共 20 条

[1]

ALTORJAY I, 1987, FREE RADICALS TISSUE, P1

[2]

BEUTLER E, 1985, J LAB CLIN MED, V105, P581

[3]

BULLES H, 1975, ARZNEIMITTEL-FORSCH, V25, P902

[4]

EICHLER O, 1949, N-S ARCH EX PATH PH, V206, P674