TOTAL SYNTHESIS OF (-)-PYRIMIDOBLAMIC ACID AND DEGLYCOBLEOMYCIN A2

被引：40

作者：

BOGER, DL

MENEZES, RF

HONDA, T

机构：

[1] Department of Chemistry, Scripps Research Institute, La Jolla, California, 92307

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1993年 / 32卷 / 02期

关键词：

D O I：

10.1002/anie.199302731

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bleomycin is an important antibiotic for the treatment of cancer. Now the completion of the total synthesis of the aglycon 1 from bleomycin A2, the major component of bleomycin, has been achieved. The decisive steps are the construction of the pyrimidine part by an inverse‐electron‐demand Diels–Alder reaction and the diastereoselective addition of a stannous enolate to an imine group. (Figure Presented.) Copyright © 1993 by VCH Verlagsgesellschaft mbH, Germany

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页码：273 / 275

页数：3

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