A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR CHLOROPENTAFLUOROBENZENE IN PRIMATES TO BE USED IN THE EVALUATION OF PROTECTIVE EQUIPMENT AGAINST TOXIC GASES

被引：3

作者：

CRANK, WD

VINEGAR, A

机构：

[1] ManTech Environmental Technology, Inc., Research Triangle Park, NC 27709

来源：

TOXICOLOGY AND INDUSTRIAL HEALTH | 1992年 / 8卷 / 1-2期

关键词：

INHALATION EXPOSURE; UPTAKE SIMULANT; RHESUS MONKEY; HALOGENATED AROMATIC;

D O I：

10.1177/074823379200800103

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Chloropentafluorobenzene (CPFB) has been proposed as an innocuous simulant for the uptake of toxic gases. Exposure to CPFB in a training exercise could be inferred afterwards from a measurement of CPFB in expired breath. To understand the relationship between exposure and measurement, we have developed a physiologically-based pharmacokinetic (PB-PK) model for CPFB in primates. To test the model, inhalation exposures were conducted on anesthetized rhesus monkeys. CPFB concentration in expired breath was measured during and after exposure. Simulations of CPFB uptake and clearance agreed with experimental measurements in seven of eight monkeys. A human version of the model was used to simulate exposures consisting of a single breath or a few breaths. By showing a measurable CPFB concentration in expired breath after several hours of clearance, simulations with the human model indicated the suitability of CPFB as a simulant for toxic gases.

引用

页码：21 / 35

页数：15

共 17 条

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[2]

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