EFFECTS OF THE ANTIOXIDANT BUTYLATED HYDROXYANISOLE ON CYTOSOLIC FREE CALCIUM-CONCENTRATION

被引:6
作者
DAVID, M
HORVATH, G
SCHIMKE, I
MUELLER, MM
NAGY, I
机构
[1] HEIM PAL PEDIAT HOSP,DIV CLIN CHEM,BUDAPEST,HUNGARY
[2] HUMBOLDT UNIV,DEPT CLIN & PATHOL BIOCHEM,O-1086 BERLIN,GERMANY
[3] UNIV VIENNA,DEPT SURG 2,DIV CLIN BIOCHEM,A-1010 VIENNA,AUSTRIA
关键词
BUTYLATED HYDROXYANISOLE (BHA); ANTIOXIDANT; CYTOSOLIC CALCIUM; ENDOTHELIAL CELLS;
D O I
10.1016/0300-483X(93)90142-F
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of the antioxidant butylated hydroxyanisole on free intracellular calcium was investigated in rat cardiomyocytes, rat pituitary cells, human umbilical vein endothelial cells, granulocytes and BHK-cells. The effects of incubation time and butylated hydroxyanisole (BHA) concentrations were examined with respect to the extracellular calcium concentration. Butylated hydroxyanisole increased the free cytosolic calcium concentration in a dose- and time-dependent manner irrespective of the presence of extracellular calcium. Differences between all cell types were observed in the sequel of the re-uptake of the calcium ions released by BHA. Dependence on the concentration of extracellular calcium on the extent of sequestration was seen in rat pituitary cells and cardiomyocytes only.
引用
收藏
页码:115 / 121
页数:7
相关论文
共 15 条
[1]   INHIBITION BY ANTIOXIDANTS OF AGONIST EVOKED CYTOSOLIC CA++ INCREASE, ATP SECRETION AND AGGREGATION OF ASPIRINATED HUMAN-PLATELETS [J].
ALEXANDRE, A ;
DONI, MG ;
PADOIN, E ;
DEANA, R .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 139 (02) :509-514
[2]   PERMEABILITY OF INNER MITOCHONDRIAL-MEMBRANE AND OXIDATIVE STRESS [J].
CARBONERA, D ;
AZZONE, GF .
BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 943 (02) :245-255
[3]  
DORNAND J, 1989, IMMUNOLOGY, V68, P384
[4]   FUNCTIONAL IMPLICATIONS OF CAMP AND CA2+ ON PROSTAGLANDIN-I(2) AND THROMBOXANE-A(2) SYNTHESIS BY HUMAN ENDOTHELIAL-CELLS [J].
GRIESMACHER, A ;
WEIGEL, G ;
DAVID, M ;
HORVATH, G ;
MUELLER, MM .
ARTERIOSCLEROSIS AND THROMBOSIS, 1992, 12 (04) :512-518
[5]  
GRYNKIEWICZ G, 1985, J BIOL CHEM, V260, P3440
[6]   FINE-STRUCTURE OF VASCULAR ENDOTHELIUM IN CULTURE [J].
HAUDENSCHILD, CC ;
COTRAN, RS ;
GIMBRONE, MA ;
FOLKMAN, J .
JOURNAL OF ULTRASTRUCTURE RESEARCH, 1975, 50 (01) :22-32
[7]   CULTURE OF HUMAN ENDOTHELIAL CELLS DERIVED FROM UMBILICAL VEINS - IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGICAL CRITERIA [J].
JAFFE, EA ;
NACHMAN, RL ;
BECKER, CG ;
MINICK, CR .
JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (11) :2745-2756
[8]   SYNTHESIS OF ANTIHEMOPHILIC FACTOR ANTIGEN BY CULTURED HUMAN ENDOTHELIAL CELLS [J].
JAFFE, EA ;
HOYER, LW ;
NACHMAN, RL .
JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (11) :2757-2764
[9]  
MUELLER GM, 1987, Z MED LAB DIAGN, V28, P185
[10]  
RAPPAY G, 1973, IN VITRO CELL DEV B, V8, P301