EFFECTS OF THE ANTIOXIDANT BUTYLATED HYDROXYANISOLE ON CYTOSOLIC FREE CALCIUM-CONCENTRATION

被引：6
作者：
DAVID, M
HORVATH, G
SCHIMKE, I
MUELLER, MM
NAGY, I
机构：
[1] HEIM PAL PEDIAT HOSP,DIV CLIN CHEM,BUDAPEST,HUNGARY
[2] HUMBOLDT UNIV,DEPT CLIN & PATHOL BIOCHEM,O-1086 BERLIN,GERMANY
[3] UNIV VIENNA,DEPT SURG 2,DIV CLIN BIOCHEM,A-1010 VIENNA,AUSTRIA
来源：
TOXICOLOGY | 1993年 / 77卷 / 1-2期
关键词：
BUTYLATED HYDROXYANISOLE (BHA); ANTIOXIDANT; CYTOSOLIC CALCIUM; ENDOTHELIAL CELLS;
D O I：
10.1016/0300-483X(93)90142-F
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of the antioxidant butylated hydroxyanisole on free intracellular calcium was investigated in rat cardiomyocytes, rat pituitary cells, human umbilical vein endothelial cells, granulocytes and BHK-cells. The effects of incubation time and butylated hydroxyanisole (BHA) concentrations were examined with respect to the extracellular calcium concentration. Butylated hydroxyanisole increased the free cytosolic calcium concentration in a dose- and time-dependent manner irrespective of the presence of extracellular calcium. Differences between all cell types were observed in the sequel of the re-uptake of the calcium ions released by BHA. Dependence on the concentration of extracellular calcium on the extent of sequestration was seen in rat pituitary cells and cardiomyocytes only.
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页码：115 / 121
页数：7
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