A NEW ANTI-INFLAMMATORY COMPOUND, TIMEGADINE (N-CYCLOHEXYL-N''-4-[2-METHYLQUINOLYL]-N'-2-THIAZOLYLGUANIDINE),WHICH INHIBITS BOTH PROSTAGLANDIN AND 12-HYDROXYEICOSATETRAENOIC ACID (12-HETE) FORMATION

被引:25
作者
AHNFELTRONNE, I
ARRIGONIMARTELLI, E
机构
关键词
D O I
10.1016/0006-2952(80)90301-9
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
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页码:3265 / 3269
页数:5
相关论文
共 21 条
[1]   MECHANISM OF ENHANCEMENT BY FATTY-ACID HYDROPEROXIDES OF ANAPHYLACTIC MEDIATOR RELEASE [J].
ADCOCK, JJ ;
GARLAND, LG ;
MONCADA, S ;
SALMON, JA .
PROSTAGLANDINS, 1978, 16 (02) :179-187
[2]   ENHANCEMENT OF ANAPHYLACTIC MEDIATOR RELEASE FROM GUINEA-PIG PERFUSED LUNGS BY FATTY-ACID HYDROPEROXIDES [J].
ADCOCK, JJ ;
GARLAND, LG ;
MONCADA, S ;
SALMON, JA .
PROSTAGLANDINS, 1978, 16 (02) :163-177
[3]   INVITRO STIMULATION OF PROSTAGLANDIN SYNTHETASE BY METHYL XANTHINES [J].
AHNFELTRONNE, I .
PROSTAGLANDINS, 1978, 16 (05) :711-724
[4]  
AHNFELTRONNE I, 1979, AGENTS ACTIONS S, V4, P110
[5]  
AHNFELTRONNE I, AGENTS ACTIONS
[6]  
BRAMM E, UNPUBLISHED
[7]   EFFECTS OF MODULATORS OF ARACHIDONIC-ACID METABOLISM ON THE SYNTHESIS AND RELEASE OF SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS [J].
BURKA, JF ;
FLOWER, RJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1979, 65 (01) :35-41
[8]   ANTI-INFLAMMATORY STEROIDS INDUCE BIOSYNTHESIS OF A PHOSPHOLIPASE-A2 INHIBITOR WHICH PREVENTS PROSTAGLANDIN GENERATION [J].
FLOWER, RJ ;
BLACKWELL, GJ .
NATURE, 1979, 278 (5703) :456-459
[9]   STIMULATION OF HUMAN EOSINOPHIL AND NEUTROPHIL POLYMORPHONUCLEAR LEUKOCYTE CHEMOTAXIS AND RANDOM MIGRATION BY 12-L-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID [J].
GOETZL, EJ ;
WOODS, JM ;
GORMAN, RR .
JOURNAL OF CLINICAL INVESTIGATION, 1977, 59 (01) :179-183
[10]   PROSTAGLANDIN ENDOPEROXIDES - NOVEL TRANSFORMATIONS OF ARACHIDONIC-ACID IN HUMAN PLATELETS [J].
HAMBERG, M ;
SAMUELSS.B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (09) :3400-3404