H-1 ANTIHISTAMINES INTERACT WITH CENTRAL SIGMA-RECEPTORS

被引：16
作者：
GRAY, NM [1 ]
CONTRERAS, PC [1 ]
ALLEN, SE [1 ]
TAYLOR, DP [1 ]
机构：
[1] BRISTOL MYERS SQUIBB CO,CNS BIOL PHARMACEUT RES & DEV,WALLINGFORD,CT 06492
来源：
LIFE SCIENCES | 1990年 / 47卷 / 02期
关键词：
D O I：
10.1016/0024-3205(90)90231-F
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Several antihistamines were evaluated for their ability to interact with sigma, muscarinic and histaminic H1 binding sites in rat brain preparations. All of the antihistamines were able to interact with the sigma site, as well as the other two sites. In addition, tripelennamine was found to elicit sigma-like behaviors when administered to rats. This affinity for the sigma site suggests that the compounds may elicit some of their undesirable CNS side effects via this interaction. © 1990.
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页码：175 / 180
页数：6
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