HUMAN D-TYPE CYCLIN

被引：745
作者：
YUE, X
CONNOLLY, T
FUTCHER, B
BEACH, D
机构：
[1] Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor
来源：
CELL | 1991年 / 65卷 / 04期
关键词：
D O I：
10.1016/0092-8674(91)90100-D
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A cDNA library prepared from a human glioblastoma cell line has been introduced into a budding yeast strain that lacks CLN1 and CLN2 and is conditionally deficient for CLN3 function. We rescued a gene that we call cyclin D1. It is related to A-, B-, and CLN-type cyclins, but appears to define a new subclass within the cyclin gene family. Transcription of the cyclin D1 gene gives rise to two major transcripts through alternative polyadenylation. The cyclin D1 gene transcript and its 34 kd product are both abundant in the glioblastoma cell line of origin.
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页码：691 / 699
页数：9
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