EFFECTS OF A NEW CHOLECYSTOKININ ANTAGONIST (GE 410) ON THE SMOOTH-MUSCLE OF THE GUINEA-PIG ILEUM

被引：6
|
作者：
RAKOVSKA, A [1 ]
MILENOV, K [1 ]
HENKLEIN, P [1 ]
机构：
[1] HUMBOLDT UNIV, INST PHARMACOL & TOXICOL, O-1040 BERLIN, GERMANY
来源：
EXPERIENTIA | 1990年 / 46卷 / 10期
关键词：
[!sup]3[!/sup]H]ACh release; cholecystokinin antagonist (GE 410); Cholecystokinin octapeptide; ileac smooth muscle;
D O I：
10.1007/BF01940666
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Suc-Tyr-(SE)-Met-Gly-Trp-Met-Asp-β-phenethylamide (GE 410) competitively antagonized the contractions of smooth muscle strips from guinea pig ileum (pA2=7.6, n=0.95) induced by cholecystokinin-octapeptide (CCK8). GE 410 inhibited the electrically-induced cholinergically mediated contractile responses and the [3H]ACh release in the ileum, as well as the CCK-stimulated electrical contractile responses and the [3H]ACh release in the cholinergic nerve terminals. The results suggest the existence of CCK-receptors not only in the smooth muscles but also on the neurons. © 1990 Birkhäuser Verlag Basel.
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页码：1037 / 1041
页数：5
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