EFFECTS OF A NEW CHOLECYSTOKININ ANTAGONIST (GE 410) ON THE SMOOTH-MUSCLE OF THE GUINEA-PIG ILEUM

被引：6

作者：

RAKOVSKA, A ^{[1
]}

MILENOV, K ^{[1
]}

HENKLEIN, P ^{[1
]}

机构：

[1] HUMBOLDT UNIV, INST PHARMACOL & TOXICOL, O-1040 BERLIN, GERMANY

来源：

EXPERIENTIA | 1990年 / 46卷 / 10期

关键词：

[!sup]3[!/sup]H]ACh release; cholecystokinin antagonist (GE 410); Cholecystokinin octapeptide; ileac smooth muscle;

D O I：

10.1007/BF01940666

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Suc-Tyr-(SE)-Met-Gly-Trp-Met-Asp-β-phenethylamide (GE 410) competitively antagonized the contractions of smooth muscle strips from guinea pig ileum (pA2=7.6, n=0.95) induced by cholecystokinin-octapeptide (CCK8). GE 410 inhibited the electrically-induced cholinergically mediated contractile responses and the [3H]ACh release in the ileum, as well as the CCK-stimulated electrical contractile responses and the [3H]ACh release in the cholinergic nerve terminals. The results suggest the existence of CCK-receptors not only in the smooth muscles but also on the neurons. © 1990 Birkhäuser Verlag Basel.

引用

页码：1037 / 1041

页数：5

共 50 条

[21] LORAZEPAM INHIBITS THE EFFECTS OF CHOLECYSTOKININ OCTAPEPTIDE ON GUINEA-PIG ILEUM BUT NOT ON GUINEA-PIG GALLBLADDER
CALAM, J
MELDRUM, LA
JOURNAL OF PHYSIOLOGY-LONDON, 1986, 371 : P140 - P140
[22] EFFECTS OF AZELASTINE ON CONTRACTION OF GUINEA-PIG TRACHEAL SMOOTH-MUSCLE
LEE, HK
OHYA, Y
DOUPNIK, CA
SPERELAKIS, N
EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 187 (01) : 67 - 74
[23] RELAXANT EFFECTS OF FORSKOLIN ON GUINEA-PIG TRACHEAL SMOOTH-MUSCLE
TSUKAWAKI, M
SUZUKI, K
SUZUKI, R
TAKAGI, K
SATAKE, T
LUNG, 1987, 165 (04) : 225 - 237
[24] EFFECTS OF DICHLOROGLYOXIME ON ISOLATED GUINEA-PIG SMOOTH-MUSCLE AND ATRIUM
ABDALLA, S
KHALILI, F
DRUG AND CHEMICAL TOXICOLOGY, 1992, 15 (02) : 145 - 159
[25] EFFECTS OF GLYCERYL TRINITRATE ON GUINEA-PIG TRACHEAL SMOOTH-MUSCLE
JEONG, YG
BATTIGELLI, MC
BROMBERG, PA
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1978, 117 (04): : 133 - 133
[26] THE INFLUENCE OF HARMALINE ON THE MOVEMENTS OF SODIUM-IONS IN SMOOTH-MUSCLE OF THE GUINEA-PIG ILEUM
SULEIMAN, MS
HIDER, RC
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1985, 67 (02) : 145 - 150
[27] HETEROGENEITY IN CONTRACTILE RESPONSES OF SINGLE SMOOTH-MUSCLE CELLS FROM GUINEA-PIG ILEUM
MOMOSE, K
FANG, YI
OHATA, H
KOMATSU, Y
JAPANESE JOURNAL OF PHARMACOLOGY, 1992, 58 : P313 - P313
[28] POST-TETANIC POTENTIATION IN THE INNERVATED SMOOTH-MUSCLE PREPARATION OF THE GUINEA-PIG ILEUM
KADLEC, O
MASEK, K
SEFERNA, I
EUROPEAN JOURNAL OF PHARMACOLOGY, 1979, 60 (04) : 383 - 386
[29] MUSCARINIC CHOLINERGIC STIMULATION OF PHOSPHATIDYLINOSITOL TURNOVER IN LONGITUDINAL SMOOTH-MUSCLE OF GUINEA-PIG ILEUM
JAFFERJI, SS
MICHELL, RH
BIOCHEMICAL JOURNAL, 1976, 154 (03) : 653 - 657
[30] UNITARY POTASSIUM CURRENTS IN CULTURED SMOOTH-MUSCLE CELLS FROM THE GUINEA-PIG ILEUM
NOUAILHETAS, VLA
ABOULAFIA, J
FREDIANINETO, E
FERREIRA, AT
PAIVA, ACM
FASEB JOURNAL, 1992, 6 (01): : A380 - A380

← 1 2 3 4 5 →