THE INFLUENCE OF AZONE ON THE PERCUTANEOUS-ABSORPTION OF METHOTREXATE

被引：5

作者：

BRAIN, KR

HADGRAFT, J

LEWIS, D

ALLAN, G

机构：

[1] UNIV COLL CARDIFF,WELSH SCH PHARM,CARDIFF CF1 3XF,WALES

[2] WHITBY RES INC,RICHMOND,VA 23261

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 71卷 / 03期

关键词：

PERCUTANEOUS ABSORPTION; PENETRATION ENHANCER; AZONE; METHOTREXATE;

D O I：

10.1016/0378-5173(91)90400-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The percutaneous absorption of the polar drug methotrexate has been examined in vitro. Two alcoholic gel formulations containing 1% methotrexate with or without Azone(R) were applied to full-thickness abdominal human skin mounted in all-glass Franz-type diffusion cells. In the absence of Azone(R) no percutaneous penetration of methotrexate was observed. In the presence of Azone(R) 190 ng/cm2 permeated after 48 h. Azone(R) appears to be acting as an efficient penetration enhancer for this drug.

引用

页码：R9 / R11

页数：3

共 12 条

[1] MECHANISM OF ACTION OF AZONE AS A PERCUTANEOUS PENETRATION ENHANCER - LIPID BILAYER FLUIDITY AND TRANSITION-TEMPERATURE EFFECTS [J].