PRESYNAPTIC LOCALIZATION OF SUBSTANCE-P DEGRADATIVE ENZYMES(S) IN RAT SUBSTANTIA NIGRA

被引：7
作者：
QUIK, M [1 ]
EMSON, PC [1 ]
机构：
[1] MED SCH CAMBRIDGE,DEPT PHARMACOL,MRC,NEUROCHEM PHARMACOL UNIT,HILLS RD,CAMBRIDGE CB2 2QD,ENGLAND
来源：
NEUROSCIENCE LETTERS | 1979年 / 15卷 / 2-3期
关键词：
D O I：
10.1016/0304-3940(79)96116-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Intrastriatal injections of kainic acid in rat brain, which destroyed striatal nerve cell bodies and their axons projecting to the substantia nigra (s. nigra) decreased the rate of breakdown of exogenously added substance P by washed slice preparation of s. nigra. Injection of 6-hydroxydopamine (6-OHDA) into the s. nigra, which destroys the dopamine nerve cell bodies in this region, did not significantly affect the rate of degradation of substance P by nigral slices. Part of the peptidase activity responsible for breakdown of substance P in the s. nigra may thus be located on the terminals of striatal afferents to the s. nigra. © 1979.
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页码：217 / 222
页数：6
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