EFFECT OF AUTOLOGOUS TUMOR EXTRACTS ON CULTURED HUMAN PERIPHERAL BLOOD LYMPHOCYTES

被引：0
作者：
SAVEL, H
机构：
[1] Department of Internal Medicine, University of Vermont College of Medicine, Burlington, Vermont
来源：
CANCER | 1969年 / 24卷 / 01期
关键词：
D O I：
10.1002/1097-0142(196907)24:1<56::AID-CNCR2820240106>3.0.CO;2-Z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Autologous crude saline extracts of human tumors were incubated with cultures of autologous human lymphocytes, and the degree of stimulation of the lymphocytes was quantitated by tritiated thymidine uptake. While no degree of stimulation was seen in 44 patients, a suggestive elevation was seen in 5 patients and a definite elevation (T:C ratio > 2) in 7 patients. These 7 patients all had tumors with a relatively favorable prognosis, including one patient with malignant melanoma who was undergoing spontaneous regression. It is suggested that the determination of lymphocyte hypersensitivity to autologous tumors may have ultimate prognostic significance. Copyright © 1969 American Cancer Society
引用
收藏
页码：56 / &
相关论文
共 50 条
[41]   INVITRO POLYCLONAL ACTIVATION OF HUMAN PERIPHERAL-BLOOD LYMPHOCYTES BY LEISHMANIA-DONOVANI EXTRACTS [J].
MADEIRA, ED ;
CAMPOSNETO, A ;
BUNNMORENO, MM .
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1985, 18 (5-6) :A606-A606
[42]   Immunostimulation effect of the fermented milk on human hybridomas and peripheral blood lymphocytes [J].
Sugahara, Takuya ;
Nakamoto, Katsunori ;
Hara, Kazushi .
ANIMAL CELL TECHNOLOGY: BASIC & APPLIED ASPECTS, VOL 14, 2006, :185-+
[43]   In vitro analysis of the effect of Go Ark on Human Peripheral Blood Lymphocytes [J].
Gautam, Daya Shankar ;
Marskole, Prahlad ;
Mishra, Saraswati ;
Tiwari, Nisha ;
Kumari, Anjali ;
Dwivedi, Sakshi ;
Naz, Kahkashan .
INTERNATIONAL JOURNAL OF AYURVEDIC MEDICINE, 2020, 11 (03) :410-414
[44]   CELL CALCIUM IN HUMAN PERIPHERAL-BLOOD LYMPHOCYTES AND THE EFFECT OF MITOGEN [J].
DEUTSCH, C ;
PRICE, MA .
BIOCHIMICA ET BIOPHYSICA ACTA, 1982, 687 (02) :211-218
[45]   EFFECT OF TEMPERATURE ON INVITRO TRANSFORMATION OF HUMAN PERIPHERAL-BLOOD LYMPHOCYTES [J].
ASHMAN, RB ;
GOMEZBARRETO, JN ;
NAHMIAS, AJ .
FEDERATION PROCEEDINGS, 1976, 35 (03) :821-821
[46]   Pycnoporellus fulgens extracts induce micronuclei in cultured human lymphocytes [J].
Steinmetz, MD ;
Rascol, JP ;
Orsière, T ;
Régli, P ;
Andary, C ;
Botta, A .
MEDICAL SCIENCE RESEARCH, 1998, 26 (04) :249-251
[47]   MITOSES IN LYMPHOCYTES FROM PERIPHERAL BLOOD CULTURED IN PRESENCE OF ANTIGEN [J].
ASPEGREN, N ;
RORSMAN, H .
ACTA DERMATO-VENEREOLOGICA, 1965, 45 (04) :323-&
[48]   EFFECT OF DICHLORVOS ON CULTURED HUMAN LYMPHOCYTES [J].
DEAN, BJ .
ARCHIV FUR TOXIKOLOGIE, 1972, 30 (01) :75-85
[49]   The phytoestrogens coumoestrol and genistein induce structural chromosomal aberrations in cultured human peripheral blood lymphocytes [J].
S. E. Kulling ;
B. Rosenberg ;
E. Jacobs ;
M. Metzler .
Archives of Toxicology, 1999, 73 :50-54
[50]   The phytoestrogens coumoestrol and genistein induce structural chromosomal aberrations in cultured human peripheral blood lymphocytes [J].
Kulling, SE ;
Rosenberg, B ;
Jacobs, E ;
Metzler, M .
ARCHIVES OF TOXICOLOGY, 1999, 73 (01) :50-54
12345