A case of metastatic renal cell carcinoma treated effectively by gemcitabine and sunitinib

被引：0
|
作者：
Morizane, Shuichi [1 ]
Iwamoto, Hideto [1 ]
Yao, Akihisa [1 ]
Isoyama, Tadahiro [1 ]
Sejima, Takehiro [1 ]
Takenaka, Atsushi [1 ]
机构：
[1] Tottori Univ, Fac Med, Dept Surg, Div Urol, 36-1 Nishi Cho, Yonago, Tottori 6838503, Japan
来源：
CENTRAL EUROPEAN JOURNAL OF UROLOGY | 2012年 / 65卷 / 04期
关键词：
gemcitabine; sunitinib; metastatic renal cell carcinoma;
D O I：
10.5173/ceju.2012.04.art11
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A 60-year-old man with renal cell carcinoma developed lung metastases after treatment with left radical nephrectomy (pT3bN0M0, clear cell renal carcinoma, Fuhrman G3 >2). The patient received treatment with gemcitabine and interferon-alpha and achieved complete response after seven cycles of therapy. However, eight months later, local recurrence was discovered in the renal fossa. We changed the therapeutic strategy to sunitinib, a multi-target tyrosine kinase inhibitor. The patient achieved a complete response after twelve cycles of therapy. This case report illustrates the effective use of gemcitabine and sunitinib sequentially for a patient with metastatic renal cell carcinoma.
引用
收藏
页码：227 / 229
页数：3
相关论文
共 50 条
  • [41] Sunitinib and sorafenib in metastatic renal cell carcinoma patients with renal insufficiency
    Khan, G.
    Golshayan, A.
    Elson, P.
    Wood, L.
    Garcia, J.
    Bukowski, R.
    Rini, B.
    ANNALS OF ONCOLOGY, 2010, 21 (08) : 1618 - 1622
  • [42] Gonadal Function in Male Patients With Metastatic Renal Cell Cancer Treated With Sunitinib
    Dalla Volta, Alberto
    Delbarba, Andrea
    Valcamonico, Francesca
    Cappelli, Carlo
    Caramella, Irene
    Bergamini, Marco
    Ferlin, Alberto
    Berruti, Alfredo
    IN VIVO, 2023, 37 (01): : 410 - 416
  • [43] Management of Adverse Events in Patients with Metastatic Renal Cell Carcinoma Treated with Sunitinib and Clinical Outcomes
    Arakawa-Todo, Maki
    Yoshizawa, Takahiko
    Zennami, Kenji
    Nishikawa, Genya
    Kato, Yoshiharu
    Kobayashi, Ikuo
    Kajikawa, Keishi
    Yamada, Yoshiaki
    Matsuura, Katsuhiko
    Tsukiyama, Ikuto
    Saito, Hiroko
    Hasegawa, Takaaki
    Nakamura, Kogenta
    Sumitomo, Makoto
    ANTICANCER RESEARCH, 2013, 33 (11) : 5043 - 5050
  • [44] Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib
    Beuselinck, B.
    Karadimou, A.
    Lambrechts, D.
    Claes, B.
    Wolter, P.
    Couchy, G.
    Berkers, J.
    Paridaens, R.
    Schoffski, P.
    Mejean, A.
    Verkarre, V.
    Lerut, E.
    de la Taille, A.
    Tourani, J-M
    Bigot, P.
    Linassier, C.
    Negrier, S.
    Berger, J.
    Patard, J-J
    Zucman-Rossi, J.
    Oudard, S.
    BRITISH JOURNAL OF CANCER, 2013, 108 (04) : 887 - 900
  • [45] Single-nucleotide polymorphisms associated with outcome in metastatic renal cell carcinoma treated with sunitinib
    B Beuselinck
    A Karadimou
    D Lambrechts
    B Claes
    P Wolter
    G Couchy
    J Berkers
    R Paridaens
    P Schöffski
    A Méjean
    V Verkarre
    E Lerut
    A de la Taille
    J-M Tourani
    P Bigot
    C Linassier
    S Négrier
    J Berger
    J-J Patard
    J Zucman-Rossi
    S Oudard
    British Journal of Cancer, 2013, 108 : 887 - 900
  • [46] Outcome of Patients With Renal Cell Carcinoma Metastatic to the Brain Treated With Sunitinib Without Local Therapy
    Lim, Zita Dubauskas
    Mahajan, Anita
    Weinberg, Jeffrey
    Tannir, Nizar M.
    AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2013, 36 (03): : 258 - 260
  • [47] Could thyroid dysfunction influence outcome in sunitinib-treated metastatic renal cell carcinoma?
    Sabatier, R.
    Eymard, J. C.
    Walz, J.
    Deville, J. L.
    Narbonne, H.
    Boher, J. M.
    Salem, N.
    Marcy, M.
    Brunelle, S.
    Viens, P.
    Bladou, F.
    Gravis, G.
    ANNALS OF ONCOLOGY, 2012, 23 (03) : 714 - 721
  • [48] Sunitinib - from Paradigm Shift to Standard Treatment of Metastatic Renal Cell Carcinoma
    Bergmann, Lothar
    ONKOLOGIE, 2010, 33 : 2 - 4
  • [49] Alternative dosing schedules for sunitinib as a treatment of patients with metastatic renal cell carcinoma
    Guida, Fancesco Maria
    Santoni, Matteo
    Conti, Alessandro
    Burattini, Luciano
    Savini, Agnese
    Zeppola, Tea
    Caricato, Marco
    Cascinu, Stefano
    Tonini, Giuseppe
    Santini, Daniele
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2014, 92 (03) : 208 - 217
  • [50] Sunitinib in Clinical Practice: the Expanded Access Program for Metastatic Renal Cell Carcinoma
    Marschner, Norbert
    ONKOLOGIE, 2010, 33 : 12 - 14
12345