GENETIC-HETEROGENEITY OF APOLIPOPROTEIN-E AND ITS INFLUENCE ON PLASMA-LIPID AND LIPOPROTEIN LEVELS

被引：125
作者：
DEKNIJFF, P [1 ]
VANDENMAAGDENBERG, AMJM [1 ]
FRANTS, RR [1 ]
HAVEKES, LM [1 ]
机构：
[1] LEIDEN UNIV,DEPT HUMAN GENET,2300 RA LEIDEN,NETHERLANDS
来源：
HUMAN MUTATION | 1994年 / 4卷 / 03期
关键词：
APOLIPOPROTEIN (APO) E; FAMILIAL DYSBETALIPOPROTEINEMIA (FD); TYPE III HYPERLIPOPROTEINEMIA; POLYMORPHISMS; MUTATIONS; ATHEROSCLEROSIS;
D O I：
10.1002/humu.1380040303
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Apolipoprotein E (apoE) is one of the major protein constituents of chylomicron and very-low-density lipoprotein (VLDL) remnants and plays a central role as a ligand in the receptor-mediated uptake of these particles by the liver. Including the most common variant, apoE3, 30 apoE variants have been characterized. At present, 14 apoE variants have been found to be associated with familial dysbetalipoproteinemia, a genetic lipid disorder characterized by elevated plasma cholesterol and triglyceride levels and an increased risk for atherosclerosis, Seven apoE variants were found to be associated with other forms of hyperlipoproteinemia. This report presents an overview of all currently known apoE variants and their effects on lipoprotein metabolism. (C) 1994 Wiley-Liss, Inc.
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页码：178 / 194
页数：17
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