NONCONVULSIVE SPIKE-WAVE DISCHARGES DO NOT INDUCE FOS IN CEREBROCORTICAL NEURONS

被引：12

作者：

WILLOUGHBY, JO

MACKENZIE, L

HISCOCK, JJ

SAGAR, S

机构：

[1] FLINDERS UNIV S AUSTRALIA,CTR NEUROSCI,BEDFORD PK,SA 5042,AUSTRALIA

[2] FLINDERS UNIV S AUSTRALIA,DEPT MED,BEDFORD PK,SA 5042,AUSTRALIA

[3] UNIV CALIF SAN FRANCISCO,VET AFFAIRS MED CTR,NEUROL SERV,SAN FRANCISCO,CA 94143

来源：

MOLECULAR BRAIN RESEARCH | 1993年 / 18卷 / 1-2期

关键词：

ABSENCE EPILEPSY; SPIKE-WAVE; AROUSAL; CEREBRAL CORTEX; FOS IMMUNOHISTOCHEMISTRY; ANIMAL MODEL;

D O I：

10.1016/0169-328X(93)90186-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immunohistochemical localisation of Fos was used as a marker of neuronal activity to demonstrate neurons active during non-convulsive spike-wave epilepsy. Fos-positive neurons in cortex and several subcortical areas were counted. In undisturbed animals Fos counts were not related to spike-wave in any region. With the electroencephalographic (EEG) recording procedure, Fos induction occurred in all regions, even after habituation. However, in central cortex, counts were found to be inversely related to spike-wave duration. This suggests that neuronal activity is not increased during spike-wave and that the central cortex in these animals is less responsive to arousal than in non-epileptic animals.

引用

页码：178 / 180

页数：3

共 16 条

[1]

[Anonymous], 1996, RON, V19, P1238, DOI [10.1111/j.1365-3040, DOI 10.1111/J.1365-2265.1977.T, DOI 10.1111/J.1365-3040]

[2]

BUZASAKI G, 1988, Journal of Neuroscience, V8, P4007

[3] EXPRESSION OF C-FOS IMMUNOREACTIVITY IN TRANSMITTER-CHARACTERIZED NEURONS AFTER STRESS [J].