INCREASED PRODUCTION OF TGF-BETA AND IL-6 BY AGED SPLEEN-CELLS

被引：34

作者：

ZHOU, DH

CHREST, FJ

ADLER, W

MUNSTER, A

WINCHURCH, RA

机构：

[1] JOHNS HOPKINS UNIV, CTR ASTHMA & ALLERGY, SCH MED, 5501 HOPKINS BAYVIEW CIRCLE, BALTIMORE, MD 21224 USA

[2] JOHNS HOPKINS UNIV, FRANCIS SCOTT KEY MED CTR, SCH MED, BALTIMORE, MD 21218 USA

[3] NIA, GERONTOL RES CTR, BALTIMORE, MD 21224 USA

来源：

IMMUNOLOGY LETTERS | 1993年 / 36卷 / 01期

关键词：

IMMUNITY; IMMUNOSENESCENCE; CYTOKINE; INTERLEUKIN;

D O I：

10.1016/0165-2478(93)90061-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aging is accompanied by a progressive decline in immunity in every species that has been studied. Despite its ubiquity, the causes of immunosenescence are unknown. Transforming growth factor beta (TGF-beta) is a cytokine with potent, immunosuppressive properties. Cells from aged mice produce increased levels of TGF-beta in vitro along with similar increases in interleukin 6 (Il-6), a cytokine which is immunosuppressive at elevated concentrations. Il-6 does not upregulate TGF-beta production, but high concentrations of Il-6 increase the percentage of cells expressing the TGF-beta receptor. Increased TGF-beta production and Il-6-induced upregulation of the TGF-beta receptor may be factors contributing to age-associated immunosuppression.

引用

页码：7 / 12

页数：6

共 18 条

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