REGULATION OF ALDOSTERONE RECEPTORS IN HYPERTENSION

被引：9

作者：

ARMANINI, D ^{[1
]}

ZENNARO, CM ^{[1
]}

MARTELLA, L ^{[1
]}

PRATESI, C ^{[1
]}

SCALI, M ^{[1
]}

ZAMPOLLO, V ^{[1
]}

机构：

[1] UNIV PADUA,OSTETR GINECOL CLIN,PADUA,ITALY

来源：

STEROIDS | 1993年 / 58卷 / 12期

关键词：

ALDOSTERONE; MINERALOCORTICOID RECEPTORS; PSEUDOHYPOALDOSTERONISM; ESSENTIAL HYPERTENSION; MINERALOCORTICOID; HYPERTENSION HYPERTENSION; MONONUCLEAR LEUKOCYTES;

D O I：

10.1016/0039-128X(93)90103-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mean mineralcorticoid receptor number in mononuclear leukocytes of patients with increased plasma aldosterone (Conn's syndrome, nephrovascular hypertension, preeclampsia) is lower than in controls and this reduction could be the consequence of a down-regulation of the receptor. A similar pattern is evident also in situations of excess of other mineralocorticoids (Cushing's syndrome, chronic licorice ingestion). In essential hypertension 20% of cases have reduced number of mineralocorticoid receptors in mononuclear leukocytes without increase of aldosterone and normal serum potassium. We postulate that in some cases with essential hypertension the reduction of mineralocorticoid receptors is an index of mineralocorticoid excess due to mineralocorticoids other than aldosterone.

引用

页码：611 / 613

页数：3

共 13 条

[1] CHARACTERIZATION OF ALDOSTERONE BINDING-SITES IN CIRCULATING HUMAN MONONUCLEAR LEUKOCYTES [J].