A conserved role for intragenic DNA methylation in alternative pre-mRNA splicing

被引：32
作者：
Oberdoerffer, Shalini [1 ]
机构：
[1] NCI Frederick, Mouse Canc Genet Program, NIH, Frederick, MD USA
来源：
TRANSCRIPTION-AUSTIN | 2012年 / 3卷 / 03期
关键词：
alternative pre-mRNA splicing; DNA methylation; RNA polymerase II;
D O I：
10.4161/trns.19816
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DNA methylome analysis in a variety of species has revealed elevated 5-methyl-cytosine at exons relative to introns. These associations raised the possibility that intragenic DNA methylation aids the spliceosome in the process of exon definition. Here, I highlight recent genome-wide associations and direct evidence linking DNA methylation to pre-mRNA splicing.
引用
收藏
页码：106 / 109
页数：4
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