SYNTHESIS OF TRIPLE [C-13(2),N-15], SINGLE (C-14), AND DOUBLE [C-14(2)] LABELED TRIMETREXATE

被引：1

作者：

HICKS, JL ^{[1
]}

HARTMAN, JD ^{[1
]}

SKEEAN, RW ^{[1
]}

HUANG, CC ^{[1
]}

KEPLER, JA ^{[1
]}

LIANG, CH ^{[1
]}

机构：

[1] RES TRIANGLE INST, RES TRIANGLE PK, NC 27709 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1991年 / 29卷 / 04期

关键词：

TRIMETREXATE; C-14; STABLE ISOTOPE; ANTICANCER; CI-898;

D O I：

10.1002/jlcr.2580290407

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method was developed for the synthesis of triple (C-13(2), N-14) labeled trimetrexate. A method for single carbon-14 labeled synthesis is also described. Modifications of the triple labeled synthesis with carbon-14 produced a doubled carbon-14 labeled trimetrexate.

引用

页码：415 / 429

页数：15

共 10 条

[1]

Buckingham J., 1982, DICT ORGANIC COMPOUN, V2

[2] FOLATE ANTAGONISTS .20. SYNTHESIS AND ANTI-TUMOR AND ANTI-MALARIAL PROPERTIES OF TRIMETREXATE AND RELATED 6-[(PHENYLAMINO)METHYL]-2,4-QUINAZOLINEDIAMINES [J].