Partial blockage of hepatocyte maturation in hepatoma-derived growth factor transgenic mice

被引：1
作者：
Enomoto, Hirayuki [1 ]
Nakamura, Hideji [1 ]
Komatsu-Kanatani, Naoko [2 ]
Liu, Yu [2 ]
Yoshida, Kenya [2 ]
Okuda, Yorihide [2 ]
Yamamoto, Teruhisa [1 ]
Liu, Weidong [1 ]
Nishiguchi, Shuhei [1 ]
机构：
[1] Hyogo Coll Med, Div Hepatobiliary & Pancreat Med, Dept Internal Med, Mukogawa Cho 1-1, Nishinomiya, Hyogo 6638501, Japan
[2] Osaka Univ, Dept Mol Med, Grad Sch Med, Suita, Osaka 5650871, Japan
来源：
WORLD JOURNAL OF HEPATOLOGY | 2009年 / 1卷 / 01期
关键词：
Hepatoma-derived growth factor; Hepatocyte; Maturation; Transgenic mice;
D O I：
10.4254/wjh.v1.i1.98
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
AIM: To investigate the role of hepatoma-derived growth factor (HDGF) in liver development, especially in the hepatocyte differentiation. METHODS: We generated transgenic mice which overexpressed HDGF in hepatocytes under the transcriptional control of mouse albumin promoter/enhancer. To examine the effects of HDGF overexpression on hepatocyte differentiation, we investigated the expression patterns of the differentiation marker genes. RESULTS: The HDGF transgenic mice developed normally and showed no apparent abnormality in the liver. However, the gene expression patterns of the liver in adult transgenic mice were similar to those of the neonatal liver in control mice. CONCLUSION: These findings suggest that HDGF-overexpression partially suppresses hepatocyte maturation. (C) 2009 Baishideng. All rights reserved.
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页码：98 / 102
页数：5
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