NANOMOLAR CONCENTRATIONS OF NITRIC-OXIDE REVERSIBLY INHIBIT SYNAPTOSOMAL RESPIRATION BY COMPETING WITH OXYGEN AT CYTOCHROME-OXIDASE

被引：882
作者：
BROWN, GC
COOPER, CE
机构：
[1] UNIV LONDON UNIV COLL,DEPT BIOCHEM & MOLEC BIOL,LONDON WC1E 6BT,ENGLAND
[2] UNIV LONDON UNIV COLL,SCH MED,DEPT PAEDIAT,LONDON WC1E 6JJ,ENGLAND
来源：
FEBS LETTERS | 1994年 / 356卷 / 2-3期
关键词：
NITRIC OXIDE; CYTOCHROME OXIDASE; SYNAPTOSOME; OXYGEN;
D O I：
10.1016/0014-5793(94)01290-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nitric oxide (NO) reversibly inhibited oxygen consumption of brain synaptosomes. Inhibition was reversible, occurred at the level of cytochrome oxidase, and was apparently competitive with oxygen, with half-inhibition by 270 nM NO at oxygen concentrations around 145 mu M and by 60 nM NO at around 30 mu M O-2. Isolated cytochrome oxidase was inhibited by similar levels of NO. These levels of NO are within the measured physiological and pathological range for a number of tissues and conditions, suggesting that NO inhibition of cytochrome oxidase and the competion with oxygen may occur in vivo.
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页码：295 / 298
页数：4
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