CONTROLLED-RELEASE OF ANTICANCER DRUG METHOTREXATE FROM BIODEGRADABLE GELATIN MICROSPHERES

被引：70

作者：

NARAYANI, R ^{[1
]}

RAO, KP ^{[1
]}

机构：

[1] CENT LEATHER RES INST,BIOMAT LAB,MADRAS 600020,TAMIL NADU,INDIA

来源：

JOURNAL OF MICROENCAPSULATION | 1994年 / 11卷 / 01期

关键词：

Microspheres;

D O I：

10.3109/02652049409040439

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Biodegradable hydrophilic gelatin microspheres containing the anticancer drug methotrexate (MTX) of different mean particle sizes (1-5, 5-10, and 15-20 mum) were prepared by polymer dispersion technique and crosslinked with glutaraldehyde. The microspheres were uniform, smooth, solid and in the form of free-flowing powder. About 80 per cent of MTX was incorporated in gelatin microspheres of different sizes. The in vitro release of MTX was investigated in two different media, namely simulated gastric and intestinal fluids. The release profiles indicated that gelatin microspheres released MTX in a zero-order fashion for 4-6 days in simulated gastric fluid and for 5-8 days in simulated intestinal fluid. The rate of release of MTX decreased with increase in the particle size of the microspheres. MTX release was faster in gastric fluid when compared to intestinal fluid.

引用

页码：69 / 77

页数：9

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