SURVIVAL AND TRANSMITTER EXPRESSION OF RAT CHOLINERGIC MEDIAL SEPTAL NEURONS DESPITE REMOVAL OF HIPPOCAMPUS IN THE EARLY POSTNATAL-PERIOD

被引：11
|
作者：
PLASCHKE, M
KASPER, EM
NAUMANN, T
FROTSCHER, M
机构：
[1] Institute of Anatomy, University of Freiburg, D-79001 Freiburg
来源：
NEUROSCIENCE LETTERS | 1994年 / 176卷 / 02期
关键词：
NEURONAL DEVELOPMENT; SEPTOHIPPOCAMPAL PROJECTION; CHOLINE ACETYLTRANSFERASE; N-METHYL-D-ASPARTATE; EXCITOTOXIC LESION;
D O I：
10.1016/0304-3940(94)90092-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
It has been shown that target-derived neurotrophins are not necessary for the survival of septohippocampal cholinergic neurons in adult rats. In this study, we have removed the hippocampus in early postnatal rats by unilateral excitotoxic N-methyl-D-aspartate lesions at postnatal days 5, 10 and 20. At postnatal day 70, numerous cholinergic neurons (60% of controls) were present in the medial septum on the lesioned side. This suggests that there is only a limited influence of target-derived neurotrophic factors to these cells also in development.
引用
收藏
页码：243 / 246
页数：4
相关论文
共 11 条
12