QUANTITATIVE CHARACTERIZATION OF ANTIGENS USING MONOCLONAL-ANTIBODY REACTIVITIES

被引：0
作者：
DOPAZO, J
TABERNER, A
MOYA, A
机构：
[1] CSIC,CTR INVEST BIOL,UEI FITOPATOL,E-28006 MADRID,SPAIN
[2] UNIV VALENCIA,DEPT GENET,E-46100 VALENCIA,SPAIN
来源：
COMPUTER APPLICATIONS IN THE BIOSCIENCES | 1993年 / 9卷 / 01期
关键词：
D O I：
暂无
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
A multipurpose program that empirically relates antigenic reactivities with monoclonal antibodies (MAbs) to genetic distances is presented. The program uses a set of known genetic pairwise distances to weigh each MAb depending on its capacity to define groups of taxonomically related antigens. This allows highly accurate identification and classification of unknown antigens. Also, the weights obtained constitute a quantitative measure of epitope conservation and can be used for improved vaccine design.
引用
收藏
页码：101 / 107
页数：7
相关论文
共 23 条
[1]  
[Anonymous], 1987, MOL EVOLUTIONARY GEN, DOI DOI 10.7312/NEI-92038
[2]   FOOT-AND-MOUTH DISEASE [J].
BACHRACH, HL .
ANNUAL REVIEW OF MICROBIOLOGY, 1968, 22 :201-+
[3]  
BROOKSBY JB, 1968, S SERIES IMMUNOBIOLO, V8, P1
[4]  
Domingo E., 1990, Applied Virology Research, V2, P233
[5]  
Domingo E., 1988, RNA GENETICS, VIII, P3
[6]   GENE ENCODING CAPSID PROTEIN VP1 OF FOOT-AND-MOUTH-DISEASE VIRUS - A QUASISPECIES MODEL OF MOLECULAR EVOLUTION [J].
DOPAZO, J ;
SOBRINO, F ;
PALMA, EL ;
DOMINGO, E ;
MOYA, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) :6811-6815
[7]  
DOPAZO J, 1992, MOL EVOLUTION VIRUSE
[8]   ANTIGENIC STABILITY OF FOOT-AND-MOUTH-DISEASE VIRUS VARIANTS ON SERIAL PASSAGE IN CELL-CULTURE [J].
GONZALEZ, MJ ;
SAIZ, JC ;
LAOR, O ;
MOORE, DM .
JOURNAL OF VIROLOGY, 1991, 65 (07) :3949-3953
[9]   ANTIGENIC COMPARISON OF FOOT-AND-MOUTH-DISEASE VIRUS SEROTYPES WITH MONOCLONAL-ANTIBODIES [J].
GRUBMAN, MJ ;
MORGAN, DO .
VIRUS RESEARCH, 1986, 6 (01) :33-43
[10]   DEVELOPMENT OF FOOT-AND-MOUTH-DISEASE VIRUS-STRAIN CHARACTERIZATION - A REVIEW [J].
KITCHING, RP ;
KNOWLES, NJ ;
SAMUEL, AR ;
DONALDSON, AI .
TROPICAL ANIMAL HEALTH AND PRODUCTION, 1989, 21 (03) :153-166
123