REACTIVATORS OF ACHE INHIBITED BY ORGANOPHOSPHOROUS COMPOUNDS - BUTENYLENIC AND TETRAMETHYLENIC HETEROCYCLIC OXIMES .4.

A series of bis-pyridinium and bis-imidazolium compounds containing methyl, benzyl, phenyl, 4-methoxyphenyl and 4-fluorophenyl substituents in position 3 of imidazole ring linked together with tetramethylene and buthylene chain were prepared and characterized by elemental analysis, IR and NMR spectroscopy. The inhibitory power of the oximes (IC-50) and percentage of reactivation after inhibition by sarin, VX and tabun have been determined on human erythrocyte AChE. IC-50 values varied from 0.0016 to 7.7 mmol L-1. With 2 x 10(-5) mol L-1, percentage of reactivation was from 3 to 90 for sarin-, from 3 to 68 for VX- and from 1 to 74 for tabun-inhibited AChE. None of compounds reactivates soman-inhibited human erythrocyte AChE.