DUAL-ACTING THROMBOXANE RECEPTOR ANTAGONIST SYNTHASE INHIBITORS - HETEROCYCLIC VARIATIONS

被引：7
|
作者：
FAULL, AW
GASKIN, H
HADFIELD, PS
JESSUP, R
RUSSELL, K
WATKINS, WJ
WAYNE, M
机构：
[1] ICI PHARMACEUT PLC,DEPT CHEM 2,MERESIDE,ALDERLEY PK,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND
[2] ICI PHARMACEUT PLC,DEPT BIOSCI 2,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(00)80210-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The ability of 1,3-dioxanes bearing a variety of aromatic heterocycles at C4 to inhibit thromboxane synthase has been examined. Potent dual-acting thromboxane receptor antagonist/thromboxane synthase inhibitors have been discovered.
引用
收藏
页码：1181 / 1186
页数：6
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