SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF C-2 CARBOXYETHENYLTHIO-CARBAPENEM DERIVATIVES

被引：2

作者：

BASKER, MJ ^{[1
]}

CORBETT, DF ^{[1
]}

COULTON, S ^{[1
]}

SOUTHGATE, R ^{[1
]}

机构：

[1] BEECHAM PHARMACEUT,DIV RES,BROCKHAM PK,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 07期

关键词：

D O I：

10.7164/antibiotics.43.847

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A number of C-2 carboxyethenylthio-carbapenem derivatives possessing either the (5R, 6R, 8S)- or the (5R, 6S, 8R)-stereochemistries have been prepared from the olivanic acids MM 22382 (1) and MM 22383 (4), respectively. Their in vitro antibacterial activities and stabilities to human kidney homogenate are superior to those of the parent compounds, particularly in the latter series. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：847 / 857

页数：11

共 11 条

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