Multiple endocrine neoplasia similar to human subtype 2A in a dog: Medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma

被引：10

作者：

Arias, E. A. Soler ^{[1
]}

Castillo, V. A. ^{[1
]}

Trigo, R. H. ^{[2
]}

Caneda Aristarain, M. E. ^{[3
]}

机构：

[1] UBA, Fac Ciencias Vet, Area Clin Med Pequenos Anim, Hosp Escuela,Unidad Endocrinol, Ave Chorroarin 280, Buenos Aires, DF, Argentina

[2] UBA, Fac Ciencias Vet, Catedra Patol, Ave Chorroarin 280, Buenos Aires, DF, Argentina

[3] UBA, Fac Ciencias Vet, Alumna Programa Invest, Chorroarin 280, Buenos Aires, DF, Argentina

来源：

OPEN VETERINARY JOURNAL | 2016年 / 6卷 / 03期

关键词：

Calcitonin; Immunohistochemistry; MEN; 2A; Synaptophysin; Thyroglobulin;

D O I：

10.4314/ovj.v6i3.4

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Human multiple endocrine neoplasia subtype 2A (MEN 2A) is characterized by medullary thyroid carcinoma, pheochromocytoma and parathyroid hyperplasia or adenoma in the same individual. In this report, a case of a female Rottweiler with medullary thyroid carcinoma, bilateral pheochromocytoma and parathyroid adenoma was described. Clinical manifestations of muscle weakness, polydipsia, polyuria, diarrhea and weight loss were observed. Two adrenal neoplasms were identified incidentally by ultrasonography, and tumor in the left thyroid lobe was identified by palpation. Primary hyperparathyroidism was diagnosed by biochemical testing. Histopathology report was consistent with diagnosis of bilateral pheochromocytoma and parathyroid adenoma. Immunohistochemical staining was positive for calcitonin and synaptophysin, and negative for thyroglobulin, which confirmed medullary thyroid carcinoma. This case in a dog is presenting neoplastic characteristics similar to human MEN 2A and emphasizing the importance of using immunohistochemistry for confirmation.

引用

页码：165 / 171

页数：7

共 24 条

[21] Multiple endocrine neoplasias in a dog:: Corticotrophic tumour, bilateral adrenocortical tumours, and pheochromocytoma [J].