APHIDICOLIN DOES INHIBIT REPAIR REPLICATION IN HELA-CELLS

被引：106
作者：
HANAOKA, F
KATO, H
IKEGAMI, S
OHASHI, M
YAMADA, M
机构：
[1] UNIV TOKYO,DEPT AGR CHEM,BUNKYO KU,TOKYO 113,JAPAN
[2] TOKYO METROPOLITAN INST GERONTOL,DEPT BIOCHEM,ITABASHI KU,TOKYO 173,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 02期
关键词：
D O I：
10.1016/0006-291X(79)91833-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aphidicolin was shown to be a specific inhibitor of eukaryotic DNA polymerase α. We have examined the effect of aphidicolin on repair synthesis as well as replication of HeLa cell DNA, and found that it inhibits not only DNA replication but also UV-induced DNA repair in hydroxyurea-arabinosyl cytosine treated cells. © 1979.
引用
收藏
页码：575 / 580
页数：6
相关论文
共 13 条
[1]   EFFECT OF MENGOVIRUS INFECTION ON ACTIVITY OF DNA-DEPENDENT RNA POLYMERASE OF L-CELLS [J].
BALTIMORE, D ;
FRANKLIN, RM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1962, 48 (08) :1383-&
[2]   DNA-REPLICATION IN ISOLATED HELA-CELL NUCLEI [J].
BERNARD, O ;
BRENT, TP .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1973, 53 (04) :1213-1219
[3]   VARIATIONS OF DNA POLYMERASES-ALPHA AND POLYMERASES-BETA DURING PROLONGED STIMULATION OF HUMAN LYMPHOCYTES [J].
BERTAZZONI, U ;
STEFANINI, M ;
NOY, GP ;
GIULOTTO, E ;
NUZZO, F ;
FALASCHI, A ;
SPADARI, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (03) :785-789
[4]   ANTIVIRAL EFFECTS OF APHIDICOLIN, A NEW ANTIBIOTIC PRODUCED BY CEPHALOSPORIUM-APHIDICOLA [J].
BUCKNALL, RA ;
MOORES, H ;
SIMMS, R ;
HESP, B .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1973, 4 (03) :294-298
[5]   A NUCLEAR SYSTEM FOR DNA REPLICATION FROM SYNCHRONIZED HELA CELLS [J].
FRIEDMAN, DL ;
MUELLER, GC .
BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 161 (02) :455-&
[6]   DNA-SYNTHESIS IN ISOLATED HELA-NUCLEI - SYSTEM FOR CONTINUATION OF REPLICATION IN-VIVO [J].
HERSHEY, HV ;
STIEBER, JF ;
MUELLER, GC .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1973, 34 (02) :383-394
[7]   EFFECT OF CYTOSINE-ARABINOSIDE ON FREQUENCY OF SINGLE-STRAND BREAKS IN DNA OF MAMMALIAN-CELLS FOLLOWING IRRADIATION OR CHEMICAL TREATMENT [J].
HISS, EA ;
PRESTON, RJ .
BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 478 (01) :1-8
[8]   APHIDICOLIN PREVENTS MITOTIC CELL-DIVISION BY INTERFERING WITH ACTIVITY OF DNA POLYMERASE-ALPHA [J].
IKEGAMI, S ;
TAGUCHI, T ;
OHASHI, M .
NATURE, 1978, 275 (5679) :458-460
[9]   RAPID AND CONVENIENT PROCEDURE FOR THE DETECTION OF INHIBITORS OF DNA-SYNTHESIS USING STARFISH OOCYTES AND SEA-URCHIN EMBRYOS [J].
IKEGAMI, S ;
KAWADA, K ;
KIMURA, Y ;
SUZUKI, A .
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1979, 43 (01) :161-166
[10]   REVERSAL OF CHANGES IN DNA AND CHROMOSOME STRUCTURE WHICH FOLLOW INHIBITION OF UV-INDUCED REPAIR IN HUMAN CELLS [J].
JOHNSON, RT ;
COLLINS, ARS .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 80 (02) :361-369
12